Sylvain Le Marchand


 

Dr. Sylvain Le Marchand

Specialty: Confocal and Super-resolution Microscopy

Associate Scientist

University of Delaware
15 Innovation Way, Suite 123
Newark, DE 19711

Phone: (302) 831-3441
sylvain@udel.edu

 Publications

  • Le Marchand SJ and Dalva MB (2020, re-edition of 2013). New imaging tools to study synaptogenesis. Academic Press / book chapter from Cellular Migration and Formation of Neuronal Connections, Comprehensive Developmental Neuroscience, Eds Rubenstein JL, Rakic P.

  • Le Marchand SJ*, Henderson NT*, Hruska M, Hippenmeyer S, Luo L, Dalva MB (2019). Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs. Elife 8. *Authors contributed equally to this work.

  • Hruska M, Henderson N, Le Marchand SJ, Jafri H, Dalva MB (2018). Synaptic nanomodules underlie the organization and plasticity of spine synapses. Nature Neuroscience 21(5):671-682.

  • Ellens H, Meng Z, Le Marchand SJ, Bentz J (2018). Mechanistic kinetic modeling generates system-independent P-glycoprotein mediated transport elementary rate constants for inhibition and, in combination with 3D SIM microscopy, elucidates the importance of microvilli morphology on P-glycoprotein mediated efflux activity. Expert Opinion on Drug Metabolism & Toxicity 14(6):571-584 / Review.

  • Zhao X, Sehgall M, Hou Z, Cheng J, Shu S, Wu S, Guo F, Le Marchand SJ, Lin H, Chang J and Guo JT (2018). Identification of residues controlling restriction versus enhancing activities of IFITM proteins on entry of human coronaviruses. Journal of Virology 92(6).

  • Meng Z, Le Marchand S, Agnani D, Szapacs M, Ellens H, Bentz J (2017). Microvilli morphology can affect efflux active P-Glycoprotein in confluent MDCKII -hMDR1-NKI and Caco-2 cell monolayers. Drug Metabolism and Disposition 45(2):145-151 / Front cover.

  • Hruska M, Henderson NT, Xia NL, Le Marchand SJ, Dalva MB (2015). Anchoring and synaptic stability of PSD-95 is driven by ephrin-B3. Nature Neuroscience 18(11):1594-605.

  • Benninger RK, Hutchens T, Head WS, McCaughey MJ, Zhang M, Le Marchand SJ, Satin LS, Piston DW (2014). Intrinsic islet heterogeneity and gap junction coupling determine spatiotemporal Ca²⁺ wave dynamics. Biophysical Journal 107(11):2723-33.

  • Jepson JEC., Shahidullah M, Liu D, Le Marchand SJ, Liu S, Wu MN, Levitan IB, Dalva MB, and Koh K (2014). Regulation of synaptic development in Drosophila by the PDZ domain protein DYSCHRONIC. Development 141, 4548-4557

  • Shahidullah M, Le Marchand SJ, Fei H, Zhang J, Pandey UB, Dalva MB, Pasinelli P, Levitan IB (2013). Defects in synapse structure and function precede motor neuron degeneration in Drosophila models of FUS-related Amyotrophic Lateral Sclerosis. Journal of Neuroscience, 33(50):19590-8.

  • Le Marchand SJ and Piston DW (2012). Glucose decouples intracellular Ca2+ activity from glucagon secretion in mouse pancreatic islet alpha-cells. PloS One, 7(10):e47084.

  • Le Marchand SJ and Piston DW (2010). Glucose suppression of glucagon secretion: metabolic and calcium responses from alpha-cells in intact mouse pancreatic islets. Journal of Biological Chemistry, 285(19):14389-98.

  • Hilliard FA, Steele DS, Laver D., Yang Z, Le Marchand SJ, Chopra N, Piston DW, Huke S, Knollmann BC (2010). Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass. Journal of Molecular and Cellular Cardiology, 48(2):293-30.